Book Review: Acid Base Regulation and Body Temperature

Whole Body Buffers in the Regulation of Acid-Base Equilibrium

Twenty-five years ago John P. Peters with Donald D. Van Slyke wrote one of the most precise, lucid, and comprehensive accounts of acid-base equilibrium that has ever appeared in scientific literature, namely, Chapter 18 in Volume I, Interpretations, of Quantitative clinical chemistry." This account rested on the basic experimental work of Van Slyke and other investigators and especially on the ...

REGULATION OF ACID-BASE HOMEOSTASIS BY THE KIDNEY

Protecting Groups, Acid, Base, Temperature and Time

Factors affecting aspartimide formation, such as protecting groups, acidity, basicity, and temperature, were studied using the model tetrapeptide, Glu-AspGly-Thr. The aspartyl carboxyl side chain in this tetrapeptide was either free or protected as a benzyl or cyclohexyl ester. Our results showed that the cyclohexyl ester led to far less aspartimide formation during acidic or tertiary amine tre...

Consequences for acid-base regulation

Switching in acidosis of hepatic nitrogen disposal from urea synthesis to NH4 + and net glutamine production was demonstrated in the isolated perfused livers of starved male Wistar rats. Lactate was preferred to glucose as the substrate for the carbon skeleton of glutamine synthesized over the pH range 6.9-7.5. This is necessary if the switch away from a proton-producing process (ureagenesis) i...

Body temperature regulation in diabetes

The effects of type 1 and type 2 diabetes on the body's physiological response to thermal stress is a relatively new topic in research. Diabetes tends to place individuals at greater risk for heat-related illness during heat waves and physical activity due to an impaired capacity to dissipate heat. Specifically, individuals with diabetes have been reported to have lower skin blood flow and swea...